NCT07386366 Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery
| NCT ID | NCT07386366 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Medicine and Pharmacy at Ho Chi Minh City |
| Condition | Impacted Mandibular Third Molar |
| Study Type | INTERVENTIONAL |
| Enrollment | 14 participants |
| Start Date | 2025-10-07 |
| Primary Completion | 2026-04 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 14 participants in total. It began in 2025-10-07 with a primary completion date of 2026-04.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the stitches after lower impacted wisdom tooth surgery in adults aged 18 to 35 years. The main questions it aims to answer are: 1. Does triclosan-coated polyglactin 910 suture lead to better soft-tissue wound healing than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery? 2. Does triclosan-coated polyglactin 910 suture result in a lower oral bacterial load adhered to the suture material than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery? Participants will: * Have surgery to remove two similar lower impacted wisdom teeth (one on each side) * Receive triclosan-coated stitches on one side and standard stitches on the other side, with the side assignment chosen at random * Return for follow-up visits on day three, day five, and day seven after surgery for healing checks, simple ratings of pain and swelling, and collection of a small stitch sample for bacterial testing.
Eligibility Criteria
Inclusion Criteria: * Adults aged 18 to 35 years. * American Society of Anesthesiologists (ASA) physical status I or II. * Presence of two symmetric impacted mandibular third molars with the same level of difficulty according to the Pell-Gregory and Winter classification; the difference in angulation between the two third molars is no more than 15 degrees. * No use of topical or systemic antibiotics for at least 4 weeks before surgery. * Able and willing to provide written informed consent. * No active infection associated with the mandibular third molar at the time of enrollment. Exclusion Criteria: * Pregnant or breastfeeding. * Allergy to local anesthetic (2% lidocaine with 1:100,000 epinephrine) or any medications used in the study. * Radiographic findings suggestive of a tumor or cyst associated with the impacted mandibular third molar. * Participant withdraws consent or does not agree to continue participation. * Unable to attend scheduled follow-up visits. * Difference in surgical extraction time between the two procedures is 12 minutes or more. * Suture loss/loosening before completion of the final assessment time point.
Contact & Investigator
Son Hoang Le
STUDY CHAIR
Department of Oral Surgery, Faculty of Dentistry, University of Medicine and Pharmacy at Ho Chi Minh City
Frequently Asked Questions
Who can join the NCT07386366 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 35 Years, studying Impacted Mandibular Third Molar. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07386366 currently recruiting?
Yes, NCT07386366 is actively recruiting participants. Contact the research team at nlkhuyen.ths.rhm24@ump.edu.vn for enrollment information.
Where is the NCT07386366 trial being conducted?
This trial is being conducted at Ho Chi Minh City, Vietnam.
Who is sponsoring the NCT07386366 clinical trial?
NCT07386366 is sponsored by University of Medicine and Pharmacy at Ho Chi Minh City. The principal investigator is Son Hoang Le at Department of Oral Surgery, Faculty of Dentistry, University of Medicine and Pharmacy at Ho Chi Minh City. The trial plans to enroll 14 participants.