Trial Parameters
Brief Summary
The aim of this study is to understand how the gut microbiome influences how much dietary energy humans excrete via feces. This study is based on the hypothesis that levels of methane in exhaled breath represent two different gut microbiome community structures, and therefore influence fecal energy excretion differently. Moreover, this study is assessed in the context of two different diets, both isocaloric and equal in macronutrient composition, but differing in contents of fiber, resistant starch, and large particles; which are hypothesized to impact the gut microbiome differently.
Eligibility Criteria
Inclusion Criteria: * 18-65 years old * BMI:18.5-29.9 kg/m2 * Self-reported regular defecations defined as at least every second day * Willing to collect urine and stool samples at home and able to temporarily store them in their own freezer in a provided container * Willing to exclusively eat the food provided * Owning a smartphone (iOS 11.0 and onwards, or Android 5.0 and onwards) with access to the internet * Speak and understand Danish or English Exclusion Criteria: * Current pregnancy or lactation * Following a specific dietary program or diet (e.g., vegetarian, vegan, gluten-free) or unable to consume the food provided * Diagnosis of small intestinal bacterial overgrowth (SIBO), inflammatory bowel diseases (IBD), gastrointestinal obstruction, or ischemic colitis * Diagnosed chronic constipation * Regular use of diarrhea inhibitors or laxatives * Any chronic disease that can affect the outcomes of the study * Use of medications potentially altering gastric pH (proton pump inhibito