| NCT ID | NCT07789223 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Elenzia |
| Condition | Overweight |
| Study Type | INTERVENTIONAL |
| Enrollment | 200 participants |
| Start Date | 2026-09-15 |
| Primary Completion | 2027-02 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 200 participants in total. It began in 2026-09-15 with a primary completion date of 2027-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to learn whether elénzia CONTROL®, a nutritional supplement, can support weight management in adults who have either never used GLP-1 weight-loss medications or have recently stopped using them. The main question it aims to answer is: Does taking elénzia CONTROL® for 16 weeks help reduce body weight in adults who have never used GLP-1 medications or help prevent weight regain in adults who have recently stopped using them? The study will also look at changes in appetite, sugar cravings, mood, energy, diet, sleep, physical activity, stress, quality of life, and waist circumference. Researchers will compare elénzia CONTROL® with a placebo (a look-alike supplement that does not contain the active ingredients) to see whether elénzia CONTROL® has an effect on weight management. Participants will: Take two capsules of elénzia CONTROL® or placebo once a day, 30 minutes before their largest meal, for 16 weeks. Use a mobile app to record whether they have taken their capsules and complete study questionnaires and assessments. Measure and report their body weight and waist circumference throughout the study.
Eligibility Criteria
Inclusion Criteria: * Adults aged 25 to 65 years inclusive at the time of consent. * Participants must fall into one of the following cohorts: * GLP-1-naïve cohort: individuals who have never used GLP-1 receptor agonist medications. * Post-GLP-1 cohort: individuals who have discontinued GLP-1 receptor agonist therapy, with the last injection taken prior to enrolment. * Body mass index (BMI), calculated using self-reported height and weight at screening: * GLP-1-naïve cohort: BMI ≥27 kg/m² and \<40 kg/m². * Post-GLP-1 cohort: BMI \<40 kg/m², with no lower BMI limit. * Participants entering the post-GLP-1 cohort must have been on a stable GLP-1 receptor agonist dose for at least 6 months and achieved at least 10% body-weight reduction prior to discontinuation. * Participants must be capable of providing informed consent independently and demonstrate understanding of the study requirements. * Participants must be willing and able to complete study procedures remotely through a mobile application, provide self-measured weight and waist circumference data, and take the allocated study capsules daily as instructed. * Participants must have access to a compatible smartphone, reliable internet access, and their own home weighing scale. Additional participant characteristics: A prior diagnosis of prediabetes, insulin resistance, or polycystic ovary syndrome (PCOS) may be self-reported at screening for study population characterisation and subgroup analyses. These conditions are not required for eligibility and do not determine inclusion in the study. Exclusion Criteria: * Previous or current use of elénzia CONTROL®. * Current smoking or use of nicotine-containing products. * Pregnancy or breastfeeding. * Known hypersensitivity or allergy to any component of elénzia CONTROL® or the placebo, including citrus flavonoids, milk thistle extract, bitter melon extract, iodine, zinc, selenium or chromium. * Current use of insulin, sulfonylureas (e.g. gliclazide, glimepiride), warfarin, lithium, amiodarone, high-dose iodine supplements. * Current use of herbal or other dietary supplements specifically intended for weight loss, appetite control, fat burning, or blood glucose regulation. * Current use of anorexigenic medications, including sibutramine, bupropion for weight-loss indication, liraglutide, topiramate, orlistat, fluoxetine when used for appetite suppression, cannabinoids, medroxyprogesterone, megestrol, or systemic corticosteroids used as appetite stimulants. * Diagnosis of type 1 or type 2 diabetes mellitus. * History of significant endocrine disorders, including Cushing's disease or Addison's disease. * Chronic illnesses that may significantly affect food intake, weight regulation or metabolic status, including active malignancy, advanced liver disease, renal failure or acquired immunodeficiency syndrome (AIDS). * Current participation in another interventional clinical trial, or participation in an interventional study within the previous 30 days.
Contact & Investigator
Godsfavour Oghifo, BPharm, MSc
PRINCIPAL INVESTIGATOR
elénzia
Frequently Asked Questions
Who can join the NCT07789223 clinical trial?
This trial is open to participants of all sexes, aged 25 Years or older, up to 65 Years, studying Overweight. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07789223 currently recruiting?
Yes, NCT07789223 is actively recruiting participants. Contact the research team at godsfavour@elenzia.com for enrollment information.
Where is the NCT07789223 trial being conducted?
This trial is being conducted at Redditch, United Kingdom.
Who is sponsoring the NCT07789223 clinical trial?
NCT07789223 is sponsored by Elenzia. The principal investigator is Godsfavour Oghifo, BPharm, MSc at elénzia. The trial plans to enroll 200 participants.