NCT06542107 Weaning From Mechanical Ventilation in Patients With Acute Brain Injury
| NCT ID | NCT06542107 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Southeast University, China |
| Condition | Ventilator Lung |
| Study Type | OBSERVATIONAL |
| Enrollment | 406 participants |
| Start Date | 2024-08-06 |
| Primary Completion | 2025-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 406 participants in total. It began in 2024-08-06 with a primary completion date of 2025-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Acute brain injury (ABI) patients frequently necessate intubation and invasive mechanical ventilation (IMV). While some ABI patients are capable of breathing spontaneously, which is one of the main criteria of extubation and weaning. However, the rate of extubation failure was significantly higher in ABI patients compared with non-neurological critical care patients. In patients who have failed one or several trials of extubation, tracheostomy is recommend according to the latest ESICM consensus. Tracheostomy can enhance comfort, improve pulmonary hygiene and decrease sedation requirement, which could facilitate the liberation from ventilator. Numerous studies have explored the causes of weaning failure and provide various predictive models in guiding extubation and tracheostomy. Yet, due to limitations of such as small sample size or a lack of external validation, there is paucity of practical weaning algorithm tailored for ABI patients. The liberation from IMV in ABI patients still remains challenging with poor level of evidence in current guidelines or expert consensus. We aim to describe the weaning outcomes in ABI patients, and further investigate the potential predictors of weaning success in ABI patients.
Eligibility Criteria
Inclusion Criteria: * acute brain injury * age \>=18 years * invasive mechanical ventilation for at least 24 hours Exclusion Criteria: * tracheostomized before ICU admission * pregnant or lactation * with cervical spinal cord injury * decision to receive palliative care within 24 hours of ICU admission
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06542107 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Ventilator Lung. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06542107 currently recruiting?
Yes, NCT06542107 is actively recruiting participants. Contact the research team at liulingdoctor@126.com for enrollment information.
Where is the NCT06542107 trial being conducted?
This trial is being conducted at Nanjing, China, Nanjing, China.
Who is sponsoring the NCT06542107 clinical trial?
NCT06542107 is sponsored by Southeast University, China. The trial plans to enroll 406 participants.