Washed Microbiota Transplantation for Tourette's Syndrome
Trial Parameters
Brief Summary
This study aimed to evaluate the efficacy of washed microbiota transplantation in the treatment of Tourette's syndrome (TS).
Eligibility Criteria
Inclusion Criteria: 1. Patients were aged 6 to 17 years (inclusive); 2. Met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for TS; 3. Had a Yale Global Tic Severity Scale-Total Tic Score (YGTSS-TTS) of at least 20 at screening and baseline. 4. Underwent WMT. Exclusion Criteria: 1. Complicated with certain brain disease, including tumor,injury,cerebrovascular disease; 2. Complicated with other severe disease, including cancers, organ failure, heart diseases; 3. Stereotypy associated with autism spectrum disorder; 4. With a confirmed diagnosis of psychiatric diseases, such as bipolar disorders; schizophrenia and major depressive disorders; 5. Clinically significant obsessive-compulsive disorder at baseline considered to be the primary cause of impairment at baseline; 6. Medications use affecting gut microbiota such as antibiotics and probiotics three months before WMT. 7. Other neurologic disorders other than TS that could influence the evaluation of ti