NCT07812883 Volumetric Efficacy of Alveolar Ridge Preservation
| NCT ID | NCT07812883 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universidad del Desarrollo |
| Condition | Alveolar Ridge Preservation |
| Study Type | INTERVENTIONAL |
| Enrollment | 70 participants |
| Start Date | 2026-09-15 |
| Primary Completion | 2027-11-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 70 participants in total. It began in 2026-09-15 with a primary completion date of 2027-11-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to compare the effectiveness of four post-extraction socket management approaches in preserving alveolar ridge dimensions following tooth extraction in adults requiring implant-supported rehabilitation in posterior regions. The main questions it aims to answer are: * Which treatment approach provides the greatest preservation of hard- and soft-tissue dimensions 12 weeks after tooth extraction? * Does the use of a dense polytetrafluoroethylene (d-PTFE) membrane improve alveolar ridge preservation compared with approaches that do not use a membrane? * Are there differences among the treatment groups regarding postoperative healing, complications, pain, and bone regeneration? Researchers will compare spontaneous socket healing, autologous blood clot with d-PTFE membrane, autologous blood clot with leukocyte- and platelet-rich fibrin (L-PRF), and autologous blood clot with L-PRF plus d-PTFE membrane to determine which approach provides the best preservation of alveolar ridge dimensions and tissue healing. Participants will: * Undergo tooth extraction and be randomly assigned to one of four treatment groups. * Receive clinical examinations, intraoral scans, photographs, and cone-beam computed tomography (CBCT) imaging at scheduled follow-up visits. * Complete assessments of postoperative pain and oral health-related quality of life. * Undergo implant placement 12 weeks after tooth extraction, including collection of a bone biopsy for histomorphometric analysis. * Attend follow-up visits to evaluate peri-implant tissue health, marginal bone stability, and implant success up to 24 months after implant loading.
Eligibility Criteria
Inclusion Criteria: * Adults aged 18 years or older. * Requirement for tooth extraction with the possibility of subsequent implant-supported rehabilitation in the maxillary or mandibular premolar or molar regions. * Extraction sockets classified as Class I to Class Va according to the modified Cardaropoli classification. * American Society of Anesthesiologists (ASA) Physical Status I or II. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Current treatment with bisphosphonates or systemic corticosteroids. * History of head and neck radiotherapy. * Metabolic bone disorders. * Teeth presenting with acute infectious pathology at the time of extraction. * Pregnancy or breastfeeding. * Inability or unwillingness to attend scheduled follow-up visits. * Any medical or psychological condition that, in the opinion of the investigators, could interfere with study participation or data interpretation.
Contact & Investigator
Francisca c Collao, DDS
STUDY DIRECTOR
Universidad del Desarrollo
Frequently Asked Questions
Who can join the NCT07812883 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Alveolar Ridge Preservation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07812883 currently recruiting?
Yes, NCT07812883 is actively recruiting participants. Contact the research team at clmirandacar@gmail.com for enrollment information.
Where is the NCT07812883 trial being conducted?
This trial is being conducted at Santiago, Chile.
Who is sponsoring the NCT07812883 clinical trial?
NCT07812883 is sponsored by Universidad del Desarrollo. The principal investigator is Francisca c Collao, DDS at Universidad del Desarrollo. The trial plans to enroll 70 participants.