NCT06918938 Visuomotor Control in Parkinson Disease
| NCT ID | NCT06918938 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Taiwan University Hospital |
| Condition | Parkinson Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 63 participants |
| Start Date | 2025-07-19 |
| Primary Completion | 2028-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 63 participants in total. It began in 2025-07-19 with a primary completion date of 2028-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Visuomotor processing is the ability to integrate visual information into motor plans and movement correction, which is highly required in daily activities such as writing and walking. As visual impairments have been reported in people with Parkinson's disease (PD), it is likely that those impairments may affect visuomotor processing ability and subsequently impair motor performance. Furthermore, people with PD and freezing of gait (FOG) have exhibited poorer visual perception than those without FOG, yet the differences of visuomotor control have not been well investigated. Additionally, little did the studies apply neurophysiological assessment to investigate the associated neural mechanisms. This study aims to investigate behavioral and neurophysiological differences in visuomotor control among people with PD and FOG (freezers), without FOG (non-freezers), and age-matched healthy controls. Sixty-three participants, 21 freezers, 21 non-freezers, and 21 age-matched healthy controls, will be enrolled in this study. Behavioral assessments, including a manual control task and visual perception tests will be used to evaluate visuomotor and visual perceptual abilities. Neurophysiological correlates, including corticomotor excitability and corticocortical connectivity between V1-M1 and PPC-M1, will be examined using transcranial magnetic stimulation. It is hypothesized that freezers will demonstrate the greatest visuomotor impairments and disrupted corticocortical connectivity compared to non-freezers and controls. By integrating behavioral and neurophysiological outcomes, this study seeks to unravel the mechanisms linking visual and motor impairments to FOG, ultimately providing insights into targeted interventions to improve visuomotor processing and motor performance in PD.
Eligibility Criteria
Inclusion Criteria: * age above 18 * able to follow the researchers' instructions * normal or correct-to-normal vision to view a computer screen Exclusion Criteria: * neurological disorders other than PD * diagnosed psychological disorders or a tendency of anxiety and/or depression * a self-history of seizure or a family history of epilepsy * deep brain stimulation or pacemaker implanted * unstable cardiovascular diseases or other uncontrolled medical conditions * pregnant * surgical history, severe injury, or severe tremor of their upper extremities that can affect their movements in the past 6 months
Contact & Investigator
Graduate Institute of Physical Therapy
PRINCIPAL INVESTIGATOR
National Taiwan University
Frequently Asked Questions
Who can join the NCT06918938 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Parkinson Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06918938 currently recruiting?
Yes, NCT06918938 is actively recruiting participants. Contact the research team at yayunlee@ntu.edu.tw for enrollment information.
Where is the NCT06918938 trial being conducted?
This trial is being conducted at Taipei, Taiwan.
Who is sponsoring the NCT06918938 clinical trial?
NCT06918938 is sponsored by National Taiwan University Hospital. The principal investigator is Graduate Institute of Physical Therapy at National Taiwan University. The trial plans to enroll 63 participants.
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