NCT06727942 Virtual Reality-Infused Treadmill Training on Aging-Related Outcomes
| NCT ID | NCT06727942 |
| Status | Recruiting |
| Phase | — |
| Sponsor | The University of Texas at Arlington |
| Condition | Adult ALL |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2022-05-10 |
| Primary Completion | 2027-08-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2022-05-10 with a primary completion date of 2027-08-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Age-associated motor and cognitive deficits increase the risk of falls, a major cause of morbidity and mortality. Emerging evidence suggests that inflammatory mediators lead to impaired functional capacity and frailty in the elderly and suggests that immune system mediated inflammation in the brain play an important role in cognitive decline. Substantial literature has also demonstrated that age-targeted physical activity training are promising strategies for promoting the motor-cognitive process across the adult lifespan. Recently, the virtual reality (VR) application has been implemented in the neuropsychological rehabilitation settings suggesting that the VR-infused daily living activities may benefit the transfer of intervention outcomes and to promote autonomy in function of daily living such as cooking or grocery shopping. However, it remains unclear the effect of the VR-based exercise intervention (motor-cognitive impact) on older adults' cognitive function and fall prevention. The literature suggests that the similarity of VR exercises with real life activities may improve generalizability by extending the transfer of gains of training to everyday living and promote some aspects of quality of life in older adults. It is also unclear to what extent these aging-associated motor- cognitive changes may be affected by VR rehab games and whether systemic- and neuro-inflammation is ameliorated by this novel intervention in older adults. This purpose of this study is to design and implement a Virtual Reality-Infused Treadmill Training on Aging-Related Outcomes (V-TARGET) intervention, focusing on adults (aged up to 75 years old). The study will compare the effects of V-TARGET intervention (self-paced treadmill-simulator exercise with VR rehab games) against a control group on motor-cognitive function, health-related quality of life (HRQOL), circulating inflammatory markers and cerebral/peripheral blood flow through this 5-week intervention (2 times/week, 30-minutes/session, 10 sessions total).
Eligibility Criteria
Inclusion Criteria: 1. adults aged up to 75 years old 2. able to walk independently, without use of an assistive device 3. English speaking Exclusion Criteria: 1. self-disclosed limited mobility in joint(s) due to arthritis or other condition that would prevent participation 2. any ongoing orthopedic injury 3. cardiac surgery or any ongoing cardiovascular issues preventing participation or physical activity. 4. motor/cognitive disorders (Alzheimer's disease, Parkinson's disease, dementia, etc.) 5. use of a wheelchair
Contact & Investigator
Xiangli Gu
PRINCIPAL INVESTIGATOR
University of Texas at Arlington
Frequently Asked Questions
Who can join the NCT06727942 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Adult ALL. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06727942 currently recruiting?
Yes, NCT06727942 is actively recruiting participants. Contact the research team at xiangli.gu@uta.edu for enrollment information.
Where is the NCT06727942 trial being conducted?
This trial is being conducted at Arlington, United States.
Who is sponsoring the NCT06727942 clinical trial?
NCT06727942 is sponsored by The University of Texas at Arlington. The principal investigator is Xiangli Gu at University of Texas at Arlington. The trial plans to enroll 60 participants.