NCT06887231 Virtual Reality and Neurostimulation for Early Stroke Rehabilitation
| NCT ID | NCT06887231 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Medical University of Vienna |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 35 participants |
| Start Date | 2025-03-17 |
| Primary Completion | 2026-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 35 participants in total. It began in 2025-03-17 with a primary completion date of 2026-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Stroke is one of the leading causes of disability, leaving millions of individuals each year impaired with lasting motor and sensory impairments. In the subacute phase, which goes from the first week to 3 months post-stroke, the patient has the highest recovery, which could be boosted by proper technologies intended for the rehabilitation of the patients. The impairments that the patients experience are extremely heterogeneous and go from muscle weakness to spasticity of the paretic side of the body. Beyond motor deficits, stroke survivors also suffer from sensory impairment (they do not properly feel with the paretic side of their body), impaired body representation (misjudging the size, position, and movement of their affected limb), which can further hinder recovery. Traditional rehabilitation primarily targets motor function, often without considering at all the role of sensory feedback and body perception in the recovery process. However, growing evidence suggests that the combination of multiple sensory modalities towards a multifaceted rehabilitation can enhance neuroplasticity and improve rehabilitation outcomes. To address this, the investigators have developed a novel rehabilitation approach that integrates immersive virtual reality (VR) with transcutaneous electrical nerve stimulation (TENS). This system allows stroke patients to interact with a virtual environment while receiving synchronized tactile stimulation, reinforcing sensorimotor integration. Unlike conventional therapy, which relies on passive or repetitive exercises, this approach engages patients in active, goal-oriented movements, tailored to their individual recovery progress. By focusing on the subacute stroke population, this project aims to leverage the brain's heightened plasticity during early recovery to maximize functional improvements. The VR-based intervention will adapt to each patient's motor abilities, providing real-time feedback to encourage precise movements and enhance sensory processing. Through this multisensory experience, the investigators seek to improve not only motor control but also sensory and body representation measures.
Eligibility Criteria
Inclusion Criteria: * Confirmed diagnosis of ischemic or hemorrhagic stroke * In the subacute phase (from 7 days to 3 months from last stroke onset) * Fugl-Meyer-Upper Extremity (FMUE) scale for the motor part: FMUE ≥ 10 * Ability to sit in an upright position * Age between 18 and 80 years Exclusion Criteria: * Other neurological or physical impairment or mental condition that, in the judgment of the investigator, does not allow participation in the study. * Mini-Mental State Examination (MMSE) \< 24 * Epilepsy * Nausea, headaches or fatigue due to VR-generated environment ("virtual reality motion sickness") * Peripheral nerve damage in the affected arm or hand * Pacemaker or other electronic implants
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06887231 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06887231 currently recruiting?
Yes, NCT06887231 is actively recruiting participants. Contact the research team at andrea.cimolato@meduniwien.ac.at for enrollment information.
Where is the NCT06887231 trial being conducted?
This trial is being conducted at Vienna, Austria.
Who is sponsoring the NCT06887231 clinical trial?
NCT06887231 is sponsored by Medical University of Vienna. The trial plans to enroll 35 participants.
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