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Recruiting NCT05865054

Vascular MRI Evaluation in Giant Cell Arteritis (VEGA)

Trial Parameters

Condition Giant Cell Arteritis
Sponsor University of Pennsylvania
Study Type OBSERVATIONAL
Phase N/A
Enrollment 400
Sex ALL
Min Age 50 Years
Max Age N/A
Start Date 2020-07-29
Completion 2030-07
Interventions
Magnetic Resonance Imaging (MRI)

Brief Summary

The research study is being conducted to determine the utility of magnetic resonance imaging (MRI) in identifying inflammation of arteries supplying blood to the head, brain, and eyes. The target population includes patient with suspected giant cell arteritis (GCA; temporal arteritis).

Eligibility Criteria

Inclusion Criteria: * Age 50 years or older * First presentation of suspected GCA * New or worsening cranial manifestations within 4 weeks of enrollment concerning for active GCA * Elevated CRP greater than 1.0 mg/dl * Plan to undergo temporal artery biopsy or ultrasound for diagnosis Exclusion Criteria: * Contra-indication to receiving MRI including: Implanted medical devices, pacemaker, and metallic foreign fragments inside body/orbits Known gadolinium allergy Women who are pregnant or nursing * Absence of cranial symptoms related to GCA (e.g., only large vessel GCA)

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