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Recruiting NCT07359755

Vaginal Mesh Surgery Versus Robotic-assisted Abdominal Mesh Surgery in the Treatment of Apical Prolapse - Prospective Randomized Non-inferiority Study

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Trial Parameters

Condition Pelvic Organ Prolapse (POP)
Sponsor University of Sao Paulo General Hospital
Study Type INTERVENTIONAL
Phase N/A
Enrollment 86
Sex FEMALE
Min Age 18 Years
Max Age N/A
Start Date 2025-09-15
Completion 2027-10
Interventions
Vaginal mesh surgery for apical prolapseRobotic-assisted abdominal mesh surgery with Upsylon device (Boston Scientific - USA) for vaginal apical prolapse

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Brief Summary

The goal of this study is to compare vaginal mesh surgery with abdominal robotic-assisted mesh surgery for the treatment of genital prolapse in women. The main questions it seeks to answer are: * Is the objective cure rate for vaginal mesh surgery non-inferior to that of the abdominal approach? * Is the use of vaginal mesh as safe as abdominal mesh?

Eligibility Criteria

Inclusion Criteria: * The study will include patients diagnosed with apical compartment genital prolapse of stage II or higher, who have an indication for surgical correction. Exclusion Criteria: * The following exclusion criteria will apply: patients who are unable or unwilling to complete validated outcome assessment instruments; those requiring concomitant surgical procedures (e.g., hysterectomy or any other intervention that may alter pelvic floor anatomy); * individuals with a prior history of pelvic radiotherapy; * patients with congenital or acquired anomalies of the urogenital or gastrointestinal systems; * and those with medical conditions that constitute a contraindication to elective surgical intervention.

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