NCT06694766 VAC-SIP-YF (Vaccination- Safety & Immunogenicity During Pregnancy- Yellow Fever)
| NCT ID | NCT06694766 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Institut Pasteur |
| Condition | Yellow Fever Vaccine |
| Study Type | INTERVENTIONAL |
| Enrollment | 270 participants |
| Start Date | 2025-03-24 |
| Primary Completion | 2028-03 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
The aim of this study is to compare the immunogenicity induced by yellow fever vaccination administered during pregnancy with that induced by vaccination outside pregnancy, and to assess the maternal and fetal tolerance of this vaccination.
Eligibility Criteria
Inclusion Criteria: Common : * Person over 18 years of age at the time of the first yellow fever vaccination * Female gender * Oral consent obtained after subject has been informed * Subject covered by Social Security with the exception of Aide Médicale d'Etat Specific to both groups : * For women vaccinated during pregnancy (case): Primary yellow fever vaccination during pregnancy * For women vaccinated outside pregnancy (control): Primary yellow fever vaccination outside pregnancy Exclusion Criteria: Criteria common to both sections (tolerance and immunogenicity): * Subject having received a second yellow fever vaccination * Persons unable to give informed consent for participation * Women born in areas where yellow fever is endemic * Female adults under legal protection (guardianship or trusteeship) Specific criteria for participants in the immunogenicity section: * Medical condition imcompatible with 18.5 mL blood * Women who have not given written consent to participate in the stu