NCT06779617 UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial
| NCT ID | NCT06779617 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Maryland, Baltimore |
| Condition | Sepsis |
| Study Type | INTERVENTIONAL |
| Enrollment | 150,000 participants |
| Start Date | 2026-02-01 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 150,000 participants in total. It began in 2026-02-01 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study is designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (cardiac arrest, death, unplanned ICU transfer, or rapid response team call). The goal of this study is to improve provider awareness of a patient's risk of these two negative outcomes by providing them with new risk scores. The primary outcome will be the time from when the risk score becomes elevated to when vital signs such as heart rate or blood pressure are measured, suggesting an increased awareness.
Eligibility Criteria
Hospital Unit Inclusion Criteria: * Units are part of a member hospital of the University of Maryland Medical System (UMMS) * Units treat inpatient patients * Units agree to participate in the study General Encounter Inclusion Criteria: * Encounter is on a participating inpatient unit * Encounter is associated with a bedded patient in the hospital * Encounter is associated with an adult (at least 18 years of age at time of admission) Additional SEPSys Encounter Inclusion Criteria: • Encounter has a SEPSys Score Additional RESCUE Encounter Inclusion Criteria: • Encounter has a RESCUE Score Exclusion Criteria: Hospital Unit Exclusion Criteria: * Unit treats exclusively outpatients or is located in an outpatient setting * Unit treats primarily or exclusively pediatric patients (patients under the age of 18 years old) * Unit treats exclusively psychiatric patients Additional SEPSys Encounter Exclusion Criteria: * Encounter is with OB for a normal delivery and the patient has yet to give birth. This encounter can become eligible once the patient has given birth. * Encounter is admitted with a diagnosis of sepsis * Sepsis was already diagnosed during the encounter This encounter will have been eligible until the patient began showing clinical signs or symptoms of sepsis or received a diagnosis of sepsis. Once they have a diagnosis or clinical signs or symptoms of sepsis, their SEPSys Score will no longer be updated. Data will continue to be collected on time of laboratory orders and treatments. Additional RESCUE Encounter Exclusion Criteria: • Encounter is admitted with a high RESCUE Score (RESCUE Score of 4)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06779617 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Sepsis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06779617 currently recruiting?
Yes, NCT06779617 is actively recruiting participants. Contact the research team at stisherman@som.umaryland.edu for enrollment information.
Where is the NCT06779617 trial being conducted?
This trial is being conducted at Baltimore, United States, Baltimore, United States, Bel Air, United States, Easton, United States and 4 additional locations.
Who is sponsoring the NCT06779617 clinical trial?
NCT06779617 is sponsored by University of Maryland, Baltimore. The trial plans to enroll 150,000 participants.