Ultrasound-guided Multilevel Erectorspinae Plane Block Versus Thoracic Epidural Analgesia for Prevention of Post Mastectomy Pain Syndrome for Breast Cancer Patients
Trial Parameters
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Brief Summary
The aim of this study is to compare the analgesic efficacy of multilevel erector spinae plane block (ESPB) vs thoracic epidural in modified radical mastectomy (MRM) regarding duration of analgesia, postoperative opioid consumption, effect on intraoperative fentanyl consumption, postoperative numerical pain rating scale and quality of life for the next 6 months.
Eligibility Criteria
Inclusion Criteria: * Female patients age ≥ 18 years and ≤ 65 Years. * Type of surgery; Modified Radical Mastectomy (MRM) * Physical status ASA II, III. * Body mass index (BMI): \> 20 kg/m2 and \< 35 kg/m2. Exclusion Criteria: * Patient refusal. * Allergy or a contraindication to the drug used in the study, e.g. local anesthetics, opioids. * History of psychological disorders. * History of chronic pain. * Contraindication to regional anesthesia e.g. sepsis, peripheral neuropathies and coagulopathy. * Advanced chronic renal disease, which is defined as a chronic kidney disease (CKD) in which there is a severe reduction in glomerular filtration rate (GFR \< 30 ml/min) and includes stages 4 and 5 of the CKD classification. * Decompensated cirrhosis, which is defined as an acute deterioration in liver function in a patient with cirrhosis and is characterized by jaundice, ascites, hepatic encephalopathy, hepatorenal syndrome, or variceal hemorrhage. * Severe heart disease which is defined a