NCT07696533 ULTIMATE Study (Carotid Ultrasound Vs CT Coronary Calcium Scoring to Reclassify Symptomatic Patients With Chronic Coronary Syndrome)
| NCT ID | NCT07696533 |
| Status | Recruiting |
| Phase | — |
| Sponsor | London North West Healthcare NHS Trust |
| Condition | Chronic Coronary Syndrome |
| Study Type | INTERVENTIONAL |
| Enrollment | 225 participants |
| Start Date | 2026-07-03 |
| Primary Completion | 2027-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 225 participants in total. It began in 2026-07-03 with a primary completion date of 2027-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
* Chest pain is one of the most common symptoms of heart disease. This could be due to narrowing in heart's blood vessels, which needs to be investigated. * Currently, people with a low risk of narrowing of heart vessels usually have a CT scan of the heart first. This scan is good at identifying those who do not have significant narrowing. However, the scan has some drawbacks, such as exposure to a small amount of radiation. * We are exploring if ultrasound of the neck vessels might give us similar kind of information as the CT scan. * You will be asked to attend the hospital for one visit to have an ultrasound scan of your neck. * The findings of your neck vessels will be compared with the CT scan of your heart vessels to see if there is a similarity.
Eligibility Criteria
Inclusion Criteria: 1. Age \> 18 years old 2. Symptomatic patients with suspected CCS, judged by the clinician to require CTCA with CAC scoring, for the diagnosis of CAD 3. Have a RF-CL 5-15%, as calculated using ESC guidelines 4. Able to give informed consent to participate in the study and its follow up Exclusion Criteria: 1. Age \<18 years old 2. Diagnosed ACS requiring hospitalization or urgent or emergent testing 3. Known CAD with prior MI, PCI, CABG or any angiographic evidence of CAD (≥50% lesion in a major epicardial vessel) 4. History of previous stroke or known peripheral vascular disease 5. Known significant cardiac congenital abnormalities 6. Pregnancy 7. Life expectancy \< 1 years 8. Unable to provide written informed consent
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07696533 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Chronic Coronary Syndrome. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07696533 currently recruiting?
Yes, NCT07696533 is actively recruiting participants. Contact the research team at lnwh-tr.cardiacresearch@nhs.net for enrollment information.
Where is the NCT07696533 trial being conducted?
This trial is being conducted at Harrow, United Kingdom.
Who is sponsoring the NCT07696533 clinical trial?
NCT07696533 is sponsored by London North West Healthcare NHS Trust. The trial plans to enroll 225 participants.