Trial Parameters
Brief Summary
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF. HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited. UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.
Eligibility Criteria
Inclusion Criteria: 1. Written informed consent 2. Diagnosis of HFpEF by a cardiologist with HF expertise, or a primary care physician with HF expertise, or a heart failure nurse 3. Natriuretic peptide levels measured Exclusion Criteria: 1. LV EF \< 40% (at screening or any previous measurement) 2. Known infiltrative cardiomyopathy (e.g., amyloid, sarcoid, lymphoma, endomyocardial fibrosis) 3. Known active myocarditis, constrictive pericarditis, or cardiac tamponade 4. Known genetic hypertrophic cardiomyopathy or obstructive hypertrophic cardiomyopathy 5. Known arrhythmogenic right ventricular cardiomyopathy 6. Known severe primary valvular heart disease 7. Known idiopathic, heritable or drug-induced pulmonary arterial hypertension 8. Heart transplantation or ventricular assist device 9. Complex congenital heart disease