NCT07284277 TTFields and Chemotherapy in Metastatic Pancreatic Adenocarcinoma (mPDAC)
| NCT ID | NCT07284277 |
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Sponsor | Clinica Universidad de Navarra, Universidad de Navarra |
| Condition | Pancreatic Adenocarcinoma Metastatic |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-10-14 |
| Primary Completion | 2027-03 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 30 participants in total. It began in 2025-10-14 with a primary completion date of 2027-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this clinical trial is to assess the safety and tolerability of TTFields in combination with chemotherapy in adults with metastatic pancreatic adenocarcinoma based on treatment-emergent adverse events of chemotherapy (modFOLFIRINOX) or device (TTFields). The main questions it aims to answer are: * Is TTFields treatment safe for the patients in combination with modFOLFIRINOX? * Are participants compliant with the treatment? * Is Is TTFields treatment effective in combination with modFOLFIRINOX against metastatic pancreatic adenocarcinoma?
Eligibility Criteria
Inclusion Criteria: All the patients should comply with the following criteria for inclusion: 1. Histological/cytological diagnosis of pancreatic adenocarcinoma. 2. The patient should be 18 years of age and older. 3. The patient has given consent to participate in the study. 4. The patient should be able to comply with all the requirements of the clinical trial. 5. Life expectancy of at least 3 months. 6. Metastatic disease with, at least, one hepatic lesion that must be accessible for biopsy. 7. Measurable disease as defined by Response Evaluation Criteria in Solid Tumor v1.1 (RECIST 1.1) apart from the liver lesion to be biopsied. 8. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. 9. Amenable and assigned by the investigator to receive therapy with modFOLFIRINOX. 10. Prior chemotherapy or radiotherapy on the neoadjuvant or adjuvant setting is allowed as long as at least six months have elapsed since last chemotherapy treatment. 11. Able to operate the Novo TTF-200T System independently or with the help of a caregiver. 12. Adequate hematologic and organ function, defined by the following laboratory test results, obtained during the screening period and before C1D1. 1. WBC higher than or equal to 2.5 x 10\^9/L. 2. ANC higher than or equal to 1.5 x 10\^9/L without granulocyte colony-stimulating factor support. 3. Platelet count higher than or equal to 100 x 10\^9/L without transfusion. 4. Hemoglobin higher than or equal to 9 g/dL. Patients may be transfused to meet this criterion. 5. Albumin higher than or equal to 2.5 g/dL. 6. Serum bilirubin lower than or equal to 1.5 times the upper limit of normal (ULN); patients with known Gilbert´s disease may have a bilirubin value lower than or equal to 3 x ULN. 7. INR and aPTT lower than or equal to 1.5 x ULN. 8. AST, ALT, lower than or equal to 5 x ULN. 9. Serum creatinine lower than or equal to 1.5 x ULN or Creatinine Clearance higher than or equal to 30ml/min (calculated using Cockcroft-Gault formula). 13. For women of childbearing potential: Negative serum pregnancy test within 14 days prior to C1D1. Agreement to remain abstinent (refrain from heterosexual intercourse) or use of contraceptive methods that result in a failure rate of lower than or equal to 1 percentage per year during the treatment period (combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal o transdermal); progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable o implantable); intrauterine device (IUD) or intrauterine hormone-releasing system (IUS); bilateral tubal occlusion or vasectomized partner) and for at least 180 days after the last study treatment. A woman is considered to be of childbearing potential if she is post-menarcheal, has not reached a postmenopausal state (higher than or equal to 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries and/or uterus). Exclusion Criteria: Patients who present any of the following criteria for exclusion cannot be included in the clinical trial: 1. Malignancies other than pancreatic cancer within 3 years prior to Cycle 1 Day 1 (C1D1) with the exceptions of those with a negligible risk of metastasis or death (e.g., expected 5-year overall survival higher than 90 percentage), treated with expected curative outcome (such as but not limited to: adequately treated in situ carcinoma of the cervix, basal squamous or melanomatous cell skin cancer, localized prostate cancer treated surgically with curative intent, ductal carcinoma in situ of the breast treated surgically with curative intent). 2. Previous treatment with chemotherapy for metastatic pancreatic ductal adenocarcinoma. 3. Untreated CNS metastases. Treatment of brain metastases, either by surgical or radiation techniques, must have been completed at least 4 weeks prior to study entry. 4. Known dihydropyrimidine dehydrogenase deficiency or thymidylate synthase gene polymorphism predisposing the patient for 5-fluorouracil (5-FU) toxicity. 5. Previous radiation therapy within 14 days prior to C1D1 and/or persistence of radiation-related adverse effects. 6. Implantable electronic medical devices in the torso, such as pacemakers. 7. Known severe hypersensitivities to medical adhesives or hydrogel, or history of severe allergic, anaphylactic, or other hypersensitivity reactions to any of the study treatments used. 8. Spinal cord compression not definitively treated with surgery and/or radiation. 9. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures. 10. Pregnant and lactating women 11. Patients who have received brivudine, sorivudine or analogues 4 weeks prior to Fluoracile administration. 12. Serious co-morbidities, including but not limited to: 1. History of significant cardiovascular disease unless the disease is well controlled. Significant cardiac disease includes second/third degree hart block; significant ischemic heart disease; poorly controlled hypertension; congestive heart failure of the New York Heart Association (NYHA) Class II or worse. 2. History of cerebrovascular accident (CVA) within 3 months prior to randomization or that is not stable. 3. Active infection or serious underlying medical condition that would impair the ability of the patient to receive protocol therapy. 4. History of any psychiatric condition that might impair patient´s ability to understand or comply with the requirements of the study or to provide consent.
Contact & Investigator
Mariano Ponz Sarvisé, MD, PhD
PRINCIPAL INVESTIGATOR
Clínica Universidad de Navarra
Frequently Asked Questions
Who can join the NCT07284277 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Pancreatic Adenocarcinoma Metastatic. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07284277 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT07284277 currently recruiting?
Yes, NCT07284277 is actively recruiting participants. Contact the research team at mponz@unav.es for enrollment information.
Where is the NCT07284277 trial being conducted?
This trial is being conducted at Pamplona, Spain, Barakaldo, Spain, Galdakao, Spain, Madrid, Spain and 1 additional location.
Who is sponsoring the NCT07284277 clinical trial?
NCT07284277 is sponsored by Clinica Universidad de Navarra, Universidad de Navarra. The principal investigator is Mariano Ponz Sarvisé, MD, PhD at Clínica Universidad de Navarra. The trial plans to enroll 30 participants.