Treatment With Indapamide in Patients With Post-Surgical Hypoparathyroidism
Trial Parameters
Brief Summary
The aim of this study is to investigate the effect of daily treatment with Indapamide for 14 days on urinary calcium excretion in patients with post surgical hypoparathyroidisme.
Eligibility Criteria
Inclusion Criteria: 1. Chronic post surgical hypoparathyroidism diagnosed \> 1 year ago 2. Age ≥ 18 years 3. Require treatment with active vitamin D ≥ 1 µg/day 4. Ionized plasma calcium between 1.15-1.25 mmol/L 5. 25(OH)D vitamin ≥ 50 nmol/L 6. Plasma magnesium \> 0.65 mmol/L 7. Able to read and understand Danish 8. Willing and able to sign the informed consent form Exclusion Criteria: 1. Estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73 m3 2. Active cancer or former (except thyroid and basal cell skin) cancer treatment \< 1 year ago 3. Pregnancy, pregnancy plans, or breastfeeding \< 1 year ago 4. Abnormal arterial pressure at time of screening defined as symptomatic hypotension or systolic blood pressure \< 100 mmHg 5. Plasma potassium \< 3.5 mmol/L 6. Any current disease that might affect the calcium metabolism such as but not limited to: 1. Recent prolonged immobility 2. Untreated diabetes (HbA1c \> 53 mmol/mol) 3. Severe liver disease or hepatic encephalopathy 4. Untrea