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Recruiting Phase 2 NCT04322890

NCT04322890 Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation

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Clinical Trial Summary
NCT ID NCT04322890
Status Recruiting
Phase Phase 2
Sponsor Hunan Province Tumor Hospital
Condition Non Small Cell Lung Cancer
Study Type INTERVENTIONAL
Enrollment 6,000 participants
Start Date 2020-04-16
Primary Completion 2026-12-24

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age N/A
Study Type INTERVENTIONAL
Interventions
OsimertinibAlectinib 150 MGCrizotinib 250 MG

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.

This trial targets 6,000 participants in total. It began in 2020-04-16 with a primary completion date of 2026-12-24.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

The purpose of this study is to assess the Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation.

Eligibility Criteria

Inclusion Criteria: 1. Understand the requirements and contents of the clinical trial, and provide a signed and dated informed consent form. 2. Age ≥ 18 years. 3. Histologically or cytologically confirmed, Stage IV NSCLC. 4. Oncogenic mutations confirmed by an accredited local laboratory, including EGFR, ALK, ROS1 etc. 5. ECOG 0-1. 6. Predicted survival ≥ 12 weeks. 7. Adequate bone marrow hematopoiesis and organ function 8. Presence of measurable lesions according to RECIST 1.1. Exclusion Criteria: The patient did not match from the Inclusion Criteria.

Contact & Investigator

Central Contact

Yongchang Zhang, MD

✉ zhangyongchang@csu.edu.cn

📞 +8613873123436

Principal Investigator

Yongchang Zhang, MD

PRINCIPAL INVESTIGATOR

Hunan Cancer Hospital

Frequently Asked Questions

Who can join the NCT04322890 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, studying Non Small Cell Lung Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

What phase is the NCT04322890 trial and what does that mean for participants?

Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.

Is NCT04322890 currently recruiting?

Yes, NCT04322890 is actively recruiting participants. Contact the research team at zhangyongchang@csu.edu.cn for enrollment information.

Where is the NCT04322890 trial being conducted?

This trial is being conducted at Changsha, China.

Who is sponsoring the NCT04322890 clinical trial?

NCT04322890 is sponsored by Hunan Province Tumor Hospital. The principal investigator is Yongchang Zhang, MD at Hunan Cancer Hospital. The trial plans to enroll 6,000 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology