NCT05973097 Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy
| NCT ID | NCT05973097 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Peking University Third Hospital |
| Condition | Oral Lichen Planus |
| Study Type | INTERVENTIONAL |
| Enrollment | 156 participants |
| Start Date | 2023-07-30 |
| Primary Completion | 2028-12-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 156 participants in total. It began in 2023-07-30 with a primary completion date of 2028-12-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa and is considered a precancerous condition. It is characterized by white reticular changes in the oral mucosa, which can progress to erosions and cause pain in severe cases. The pathogenesis of OLP is still unclear, but it is believed to be a T-lymphocyte-mediated autoimmune disease. Currently, only symptomatic treatments are available, and there is no definitive cure. In this project, we plan to use TCM differentiation to categorize OLP patients and conduct a randomized controlled clinical trial to demonstrate the enhanced therapeutic effect of paeoniflorin combined with photodynamic therapy for OLP. The implementation of this project will provide new insights into the clinical management of OLP, improve our understanding of the treatment mechanisms, and have important theoretical and clinical implications.
Eligibility Criteria
Inclusion Criteria: * patients with oral lichen planus * male or female patients older than 18 years of age * patients willing to participate with signed informed consent. Exclusion Criteria: * pregnant or lactating * had serious systemic diseases of the heart, lung, liver, and kidney, or had tumors * were unwilling to participate in the experiment.
Contact & Investigator
Zhihui Zhang
PRINCIPAL INVESTIGATOR
Peking University Third Hospital
Frequently Asked Questions
Who can join the NCT05973097 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Oral Lichen Planus. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05973097 currently recruiting?
Yes, NCT05973097 is actively recruiting participants. Contact the research team at wisdomzhangzhihui@163.com for enrollment information.
Where is the NCT05973097 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT05973097 clinical trial?
NCT05973097 is sponsored by Peking University Third Hospital. The principal investigator is Zhihui Zhang at Peking University Third Hospital. The trial plans to enroll 156 participants.