Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts
Trial Parameters
Brief Summary
The use of injectable platelet-rich fibrin (i-PRF) in both surgical and non-surgical dental treatments has become increasingly widespread. Hard tissue grafts can produce "sticky bone," and bone gain can have a positive effect on intrabony defects frequently seen in periodontal disease, compared to grafts alone. This study aims to clinically and radiographically evaluate the effectiveness of using bovine-derived xenogenic bone grafts in combination with i-PRF and bovine-derived xenogeneic bone grafts alone in patients with intrabony defects and stage III periodontitis.
Eligibility Criteria
Inclusion Criteria: * Male and female patients aged 18-65 years * Patients with Stage III Periodontitis according to the AAP-EFP 2017 Periodontal Disease Classification * PPD≥5 mm (if persistent 6 weeks after initial periodontal treatment) * Intrabony defects in the interproximal region with 2 or 3 walls and a depth of at least ≥3 mm * Non-smokers (those who smoke up to 10 per day may be included) Exclusion Criteria: * Patients under 18 years of age or older than 65 years of age * Patients unable to consent * Systemic diseases that could affect the success of surgery, such as uncontrolled diabetes * Single-walled intrabony defects * Those who have taken antibiotics, anti-inflammatory or immunosuppressive drugs, or birth control pills within the three months prior to the study * Those who have received active periodontal treatment within the last six months and periodontal surgery within the last year * Smoking more than 10 cigarettes per day * Pregnancy or breastfeeding * Those taking