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Recruiting Phase 2 NCT06842745

Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

Trial Parameters

Condition Aphasia
Sponsor University of Pennsylvania
Study Type INTERVENTIONAL
Phase Phase 2
Enrollment 24
Sex ALL
Min Age 40 Years
Max Age 85 Years
Start Date 2025-02-11
Completion 2026-08-31
Interventions
Transcranial Magnetic Stimulation (TMS)Speech-Language Therapy (SLT)

Brief Summary

The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment

Eligibility Criteria

Inclusion Criteria: * Left Hemisphere stroke * Stroke occurred more than 6 months ago * Mild Aphasia (WAB AQ score \> 85) * Proficient in English Exclusion Criteria: * Ongoing substance or alcohol abuse * Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis) * Active psychiatric disorders (i.e. bipolar disorder, schizophrenia) * Pacemaker or cardiac defibrillator * Diagnosis of tinnitus * Epilepsy, or seizure in the past 6 months

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