Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants
Trial Parameters
Brief Summary
This study examines the impact of theta-burst transcranial focused ultrasound stimulation (tFUS) on cognitive performance in healthy participants, specifically focusing on both acute and post-stimulation effects on visual working memory (vWM). The investigation will compare TUS effects across targeted deep cortical and subcortical brain regions involved in cognitive processing. Neurophysiological changes following stimulation will be assessed using EEG, providing insight into tFUS-induced modulations in working memory-related brain activity.
Eligibility Criteria
Inclusion Criteria: * Age: 18-55years * Healthy adults with no history of neurological or psychiatric disorders * Eligible to undergo a T1-weighted MRI scan for tFUS neuronavigational purposes * Ability to adhere to the tFUS study schedule and complete all assessments * Right-handed * Fluent in English * Abstinence from the use of any recreational drugs in the 48-hour period prior to taking part in the experiment. * Abstinence from consuming no more than 4 alcoholic units within the 24-hour period before participation. Exclusion Criteria: * Any current psychiatric diagnosis * Neurodevelopmental disorders; history of central nervous system disease, concussion, or other neurological sequelae; presence of tumors, seizures, meningitis, encephalitis, or any abnormal MRI findings of the brain * Use of any psychotropic medications within five half-lives before the procedure * Presence of metal implants contraindicated for MRI * History of head trauma with loss of consciousness * Calcification