NCT05903573 Training Response Artificial Intelligence Network (TRAIN)
| NCT ID | NCT05903573 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Florida |
| Condition | Amnestic Mild Cognitive Impairment |
| Study Type | INTERVENTIONAL |
| Enrollment | 75 participants |
| Start Date | 2023-10-09 |
| Primary Completion | 2028-04-30 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This study will train a machine learning tool to predict response to a cognitive training intervention using baseline brain MRI sequences from older adults with amnestic mild cognitive impairment.
Eligibility Criteria
Inclusion Criteria: * Evidence of changed cognition reported by a close informant as obtained by an interview with a licensed clinical psychologist (PI, Gullett) * Cognitive performance on one or more standardized neuropsychological measures of verbal or non-verbal memory \> 1.0 standard deviation or more below the normative mean for age and education * No evidence of reported dependence in instrumental functional abilities (IADLs) despite reported cognitive difficulties * No evidence of dementia based on cognitive screening (Montreal Cognitive Assessment Score within normal limits for age, education, and sex using the NACC Uniform Data Set (UDS) norms. * Global clinical dementia rating scale (CDR) score must be equal to 0.5 * Willingness to be randomized into either the educational training (control) or intervention (cognitive training) group * Able and willing to devote 12 weeks to the intervention with additional time for pre- and post-testing * Able and willing to perform cognitive