TRAcking Thoracic Cancer Evolution Through Therapy (Rx) EVO
Trial Parameters
Brief Summary
TRACERx EVO is a programme of work using a prospective observational cohort study of participants with early- and late-stage non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) and pleural mesothelioma.
Eligibility Criteria
Inclusion Criteria: * Cohort A, B and C : * Written Informed consent * Agreement to be followed up (including on-study assessments and sample collection) every 3 months in the first 2 years and then 6 monthly. * Agreement to be followed up at a TRACERx EVO site Cohort A: * Participants ≥18 years of age, with early stage I-IIIB NSCLC disease who are eligible for primary surgery * Histopathologically confirmed NSCLC, or a strong suspicion of cancer on lung imaging necessitating surgery (e.g., diagnosis determined from frozen section in theatre) * Primary surgery in keeping with NICE guidelines in (lobectomy, either open or thoracoscopic), lung parenchymal-sparing operations (segmentectomy or wedge resection) if a complete resection can be achieved, extensive surgery (bronchoangioplastic surgery, bilobectomy, pneumonectomy) if necessary to obtain clear margins, hilar and mediastinal lymph node sampling or en bloc resection) * For participants proceeding with upfront primary surgery (i.e.