To Evaluate the Safety and Efficacy of Pediococcus Acidilactici PA53 in Relieving Constipation in Adults
Trial Parameters
Brief Summary
To study the improvement of constipation symptoms, quality of life and mental state, intestinal function, intestinal hormones, inflammation and immunity, and intestinal flora of constipation subjects after 8-week intervention with Pediococcus acidilactici PA53.
Eligibility Criteria
Inclusion Criteria: 1\. Constipated subjects Subjects (less than 3 bowel movements per week and/or Bristol Scale Types 1 and 2); 2. Be able to complete the research according to the requirements of the test plan; 3. Subjects who have signed informed consent; 4. Subjects (including male subjects) have no family planning and voluntarily take effective contraceptive measures from 14 days before screening to 6 months after the end of the trial. \- Exclusion Criteria: 1. Short-term use of items with similar functions to the subject, which affects the judge of the result; 2. Those who changed their diet type during the study period; 3. People with severe allergies and immune deficiencies; 4. Women who are pregnant, breastfeeding or planning to become pregnant; 5. Patients with serious diseases of cardiovascular, lung, liver, kidney and other vital organs, diabetes, thyroid disease, severe metabolic diseases, malignant tumors, and severe immune system diseases; 6. People who have used antibio