NCT06608680 Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Networks
| NCT ID | NCT06608680 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Georgia State University |
| Condition | Reading |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2023-05-01 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2023-05-01 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to understand how transcranial magnetic stimulation affects how quickly, easily, and accurately a person read. Transcranial magnetic stimulation is a technique that uses magnetic fields to briefly affect how well certain brain regions function. The investigators would like to better understand how long the effects of transcranial magnetic stimulation occur in the reading system and at what point the effect is strongest in this system. The main questions it aims to answer are: 1. At what point after stimulation are the greatest effects on behavior seen 2. How excitatory and inhibitory stimulation affect behavior Researchers will compare stimulation types against a sham condition to see effects on reading and language behavior. Participants will be asked to * undergo reading, language, and cognitive testing * receive an MRI * receive TMS stimulation * perform language, reading, and motor tasks
Eligibility Criteria
Inclusion Criteria: * Subjects must have a minimum of low average intellectual functioning (\>=80) on at least one subscale on the Wechsler Abbreviated Scale of Intelligence-2 (WASI-2; Wechsler, 2011) to be included. * Within a normal range of reading skills as \>85 on the Test of Word Reading Efficiency - Second Edition (TOWRE-2; Torgesen et al., 2012) and the Woodcock-Johnson IV Tests of Achievement (WJ-IV; Schrank et al., 2014) * Individuals with a documented history of learning disability will not be included. This will be determined via demographics questionnaire. * Subjects must be between the ages of 18 and 30 to be included. This will be determined via demographics questionnaire. * Because reading is critically linked to language, only individuals who are native speakers of English will be included in the study. This will be determined via demographics questionnaire. * The reading network is typically localized to the left side of the brain. However, left-handed individuals may have different brain lateralization, introducing an important confound to the study. Therefore, only right-handed individuals will be included in the study. This will be determined via demographics questionnaire. * Individuals who have hearing deficits (\>25dB at 500+ Hz), visual deficits (\>20/40), serious emotional problems, certain neurological conditions (e.g., uncontrolled seizure disorders) will not be included. This will be determined via CABI Screening Forms and Demographics Questionnaire. * Individuals with certain metals in their bodies or with certain health conditions will not be included. If an individual has braces on their teeth, a cardiac pacemaker; hearing aid; other metal in their body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects they will not be included. This will be determined via CABI Screening forms. * Individuals with MRI Screening and Contraindication Forms which do not pass MRI Tech review will not be included. * Individuals with TMS Screening Forms which do not pass TMS Tech review will not be included.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06608680 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 30 Years, studying Reading. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06608680 currently recruiting?
Yes, NCT06608680 is actively recruiting participants. Contact the research team at rharrington2@gsu.edu for enrollment information.
Where is the NCT06608680 trial being conducted?
This trial is being conducted at Atlanta, United States.
Who is sponsoring the NCT06608680 clinical trial?
NCT06608680 is sponsored by Georgia State University. The trial plans to enroll 50 participants.