NCT07275658 Timing and Dose of Fluid Deresuscitation in Critically Ill Patients
| NCT ID | NCT07275658 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
| Condition | Fluid Overload |
| Study Type | OBSERVATIONAL |
| Enrollment | 150 participants |
| Start Date | 2025-10-15 |
| Primary Completion | 2027-01-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 150 participants in total. It began in 2025-10-15 with a primary completion date of 2027-01-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Fluid deresuscitation is an important intervention in the Intensive Care Unit (ICU). This study aims to find (1) determinants of successful deresuscitation, (2) the optimal rate (dose) of deresuscitation based on these determinants, and (3) differences in metabolic profiles for a more personalized approach of deresuscitation. This study is a multicenter, prospective, observational cohort study in critically ill patients. This study will include ICU patients who have a clinical indication for deresuscitation as set by the treating physician. Clinical, ultrasound and laboratory values will be collected and used for analysis.
Eligibility Criteria
Inclusion Criteria: * Admission to one of the participating ICUs; * Clinical indication for deresuscitation using diuretics or ultrafiltration as set by the treating physician; first attempt during the ICU stay. Exclusion Criteria: * Age below 18 years old; * Major cardiac shunts; * Moderate to severe aortic regurgitation; * Morbid Obesisty (BMI \>40); * POCUS impossible or unreliable (i.e. pre-existing interstitial lung disease); * PLR or modified form of PLR impossible (i.e. ECMO); * Transfer from another ICU; * Previous inclusion in this study; * Patients who are moribund or facing the end of life; * Opt out.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07275658 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Fluid Overload. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07275658 currently recruiting?
Yes, NCT07275658 is actively recruiting participants. Contact the research team at k.opschoor@amsterdamumc.nl for enrollment information.
Where is the NCT07275658 trial being conducted?
This trial is being conducted at Amsterdam, Netherlands, Amsterdam, Netherlands.
Who is sponsoring the NCT07275658 clinical trial?
NCT07275658 is sponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA). The trial plans to enroll 150 participants.