Trial Parameters
Brief Summary
The aim of this study is to assess whether delaying early flow through the Ahmed tube shunt may improve the post-operative surgical outcomes and provide a more predictable outcome. To assess this the investigator will conduct a, randomized prospective, multi-centered study with collaborators at WashU in St. Louis, Duke University, Indiana University and the University of Pittsburgh. Participants will be randomized to have an AGV placement with tube ligation (no-early flow) and without ligation (allowing for early flow). IOP will be measured at day one, week one, and months, one, three six, and twelve. Additionally, clinical data regarding number of glaucoma medications, and complications post-operative complications will also be collected.
Eligibility Criteria
Inclusion Criteria: * Subjects with age at screening ≥ 18 years * Inadequately controlled glaucoma or ocular hypertension * Ahmed valve implant as the planned surgical procedure * Patients with primary glaucomas (Primary Open Angle Glaucoma or Primary Angle Closure Glaucoma) or pseudoexfoliation, pigmentary and traumatic glaucoma with or without a previous failed trabeculectomy or other intraocular surgery. * Primary tubes included * Investigators to recruit consecutively all eligible patients from their clinics. * Capable and willing to provide consent Exclusion Criteria: * Subjects with NLP vision * Subjects unable/unwilling to provide informed consent * Unavailable for regular follow up * Previous cyclodestructive procedure * Prior scleral buckling procedure or other external impediment to drainage device implantation * Presence of silicone oil * Vitreous in the anterior chamber sufficient to require a vitrectomy * Uveitic glaucoma * Neovascular glaucoma * Nanophthalmos * Patients w