The Safety and Efficacy of NouvSoma001 in Neuromyelitis Optica Spectrum Disorders
Trial Parameters
Brief Summary
This is a single-center, randomized, open-label, placebo-controlled, dose-escalation trial. The objective of this research is to evaluate the safety, tolerability, and efficacy of intrathecal administration of human-induced neural stem cell-derived extracellular vesicles (NouvSoma001) for the treatment of neuromyelitis optica spectrum disorders.
Eligibility Criteria
Inclusion Criteria: 1. Patients must meet the 2015 International Consensus Diagnostic Criteria for Neuromyelitis Optica Spectrum Disorder (NMOSD) and test positive for AQP4 antibodies. 2. Symptom onset occurred within 7 days prior to enrollment, with associated severe pain, lower limb motor dysfunction, or urinary/bowel impairment. 3. Males or Females aged between 18 and 65 years. 4. The Expanded Disability Status Scale (EDSS) score prior to the current disease episode is ≤ 4. 5. Female participants of childbearing potential must present a negative pregnancy test at screening and agree to use effective contraception throughout the study period. 6. Informed consent must be obtained from the patient or their legal representative, with a signed consent form must be provided. Exclusion Criteria: 1. Abnormal laboratory indicators of the subjects need to be excluded, including, but not limited to, the following indicators: White Blood Cell Count \<3\*10\^9/L Neutrophil Count \<1.5\*10\