NCT05794087 The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
| NCT ID | NCT05794087 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Rutgers, The State University of New Jersey |
| Condition | Air Pollution |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2023-02-07 |
| Primary Completion | 2027-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2023-02-07 with a primary completion date of 2027-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.
Eligibility Criteria
Exclusion Criteria: * Cardiovascular disease * Respiratory disease * Recent (within 4 weeks) respiratory or COVID-19 symptoms * Diabetes * Pregnancy * HIV Infection * History of smoking within the past 5 years. * Orthopedic or rheumatologic conditions which would interfere with cycle use * Inability to produce a sputum plug at screening * Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.
Contact & Investigator
Howard M Kipen, MD
PRINCIPAL INVESTIGATOR
Rutgers School of Public Health
Frequently Asked Questions
Who can join the NCT05794087 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 40 Years, studying Air Pollution. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05794087 currently recruiting?
Yes, NCT05794087 is actively recruiting participants. Contact the research team at kgblack@eohsi.rutgers.edu for enrollment information.
Where is the NCT05794087 trial being conducted?
This trial is being conducted at Piscataway, United States.
Who is sponsoring the NCT05794087 clinical trial?
NCT05794087 is sponsored by Rutgers, The State University of New Jersey. The principal investigator is Howard M Kipen, MD at Rutgers School of Public Health. The trial plans to enroll 120 participants.