NCT04646252 The Role of Glycocalyx Integrity in the Primary Prevention of Major Cardiovascular Events
| NCT ID | NCT04646252 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Athens |
| Condition | Endothelial Dysfunction |
| Study Type | OBSERVATIONAL |
| Enrollment | 500 participants |
| Start Date | 2013-01-10 |
| Primary Completion | 2026-06-20 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 500 participants in total. It began in 2013-01-10 with a primary completion date of 2026-06-20.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The researchers intend to recruit individuals who are referred for a routine screening in the primary prevention outpatient clinic of Attikon University hospital, Athens According to institutional protocols, a detailed medical history for atherosclerotic risk factors and current medication is recorded and a baseline clinical examination is performed. Moreover fasting blood samples are drawn to diagnose the presence of diabetes mellitus and hyperlipidemia. Glycocalyx examination is performed at the same visit. The subjects are revaluated at one month and then followed up according to the attending physician's instructions. Pulse wave velocity and the rest pulse wave analysis parameters were also calculated to determine the additive predictive value for cardiovascular events beyond SCORE2. All subjects are followed up for adverse events (death, stroke, myocardial infarction, hospitalization for heart failure) for 6 years after enrollment via telephonic contact and planned appointment at the outpatient clinic.
Eligibility Criteria
Inclusion Criteria: We recruit individuals who were referred for a routine screening in the primary prevention outpatient clinic of Attikon University hospital. Exclusion Criteria: * History of Coronary artery disease, * History of Peripheral Arterial Disease, * History of Heart failure * History of Stroke * hepatic failure * renal failure, * active neoplasia * poorly controlled DM, defined as Hba1C\>7%
Contact & Investigator
IGNATIOS IKONOMIDIS, PROFESSOR
PRINCIPAL INVESTIGATOR
National and Kapodistrian University of Athens
Frequently Asked Questions
Who can join the NCT04646252 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 85 Years, studying Endothelial Dysfunction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04646252 currently recruiting?
Yes, NCT04646252 is actively recruiting participants. Contact the research team at ignoik@gmail.com for enrollment information.
Where is the NCT04646252 trial being conducted?
This trial is being conducted at Athens, Greece.
Who is sponsoring the NCT04646252 clinical trial?
NCT04646252 is sponsored by University of Athens. The principal investigator is IGNATIOS IKONOMIDIS, PROFESSOR at National and Kapodistrian University of Athens. The trial plans to enroll 500 participants.