NCT05884853 The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder
| NCT ID | NCT05884853 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Taiwan University Hospital |
| Condition | Autism Spectrum Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2021-01-01 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2021-01-01 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. The social brain hypothesis suggests that our brains evolve to navigate complex social systems. The social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (pSTS), the dorsal and ventral medial prefrontal cortices (dmPFC and vmPFC), ACC and posterior cingulate cortex (PCC), the amygdala, the orbital frontal cortex (OFC), and the fusiform gyrus (FG), TPJ, inferior occipital gyrus (IOG), and the insula. Each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.
Eligibility Criteria
Inclusion Criteria: * age between 18 and 50 * diagnosed with ASD from licensed mental health or medical professional based on DSM5 * have social problems * motivated to participate in the treatment * fluent in chinese * caregiver also fluent in chinese and motivated to participate * had a full-scale IQ \> 70 on WAIS-IV * scored ≧ 26 on the caregiver-reported Autism Spectrum Quotient (AQ), indicating clinical impairment associated with ASD. Exclusion Criteria: * history of major mental illness, such as bipolar affective disorder, schizophrenia, psychosis, or neurological diseases * visual impairment and/or hearing impairment * any metal, electronic part that cannot be removed from the body, or being pregnant, which may not be able to use fMRI scan.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05884853 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Autism Spectrum Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05884853 currently recruiting?
Yes, NCT05884853 is actively recruiting participants. Contact the research team at chienyiling@gmail.com for enrollment information.
Where is the NCT05884853 trial being conducted?
This trial is being conducted at Taipei, Taiwan.
Who is sponsoring the NCT05884853 clinical trial?
NCT05884853 is sponsored by National Taiwan University Hospital. The trial plans to enroll 120 participants.