NCT07539675 The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
| NCT ID | NCT07539675 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zhongnan Hospital |
| Condition | Primary Angle-Closure Glaucoma |
| Study Type | OBSERVATIONAL |
| Enrollment | 150 participants |
| Start Date | 2025-10-01 |
| Primary Completion | 2027-09-30 |
Trial Parameters
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Brief Summary
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
Eligibility Criteria
Inclusion Criteria: * Clinically diagnosed with primary angle-closure glaucoma (PACG) * Aged ≥ 50 years, no gender restriction * Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity * Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology * Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery Exclusion Criteria: * Secondary glaucoma * History of previous intraocular surgery * Systemic diseases that can cause abnormal ocular zonules * Other severe ocular diseases * Long-term use of medications affecting connective tissue metabolism