NCT07178704 The Metabolic and Genetic Drivers of Body Composition Changes Following Weight Loss Surgery
| NCT ID | NCT07178704 |
| Status | Recruiting |
| Phase | — |
| Sponsor | The University of Texas Medical Branch, Galveston |
| Condition | Bariatric Surgery Patients |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2025-11-04 |
| Primary Completion | 2027-02 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2025-11-04 with a primary completion date of 2027-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Weight loss surgery is very good at reducing body weight but it can also cause the loss of both muscle and strength. Some patients undergoing weight loss surgery do not achieve their weight loss goals and regain the weight they lost. When this occurs, the loss of muscle and strength combined with the regain of weight can impact the individual's quality of life and ability to remain active and mobile. The purpose of this study is to understand the behavioral, biological, and genetic factors that influence the success of weight loss surgery and its impact on muscle mass. Bariatric surgery patients participating in the trial will be monitored prior to, and for a year following weight loss surgery, with data collected about their eating habits, hand grip strength, and the loss of fat, muscle, and body weight following surgery. In patients who undergo a routine endoscopy in advance of weight loss surgery a small sample of gut tissue will be collected to identify the expression (activity) of genes in their DNA.
Eligibility Criteria
Inclusion Criteria (Bariatric Surgery Patients): * Age: 18 to 65 years at time of consent * BMI: 35-65 kg.m-2 * Scheduled to undergo bariatric surgery at UTMB * All races and ethnic backgrounds * Ability to speak and read English * Subject has provided informed consent in a manner approved by the IRB and is willing and able to comply with the trial procedures. Exclusion Criteria (Bariatric Surgery Patients): * Fails the medical criteria for bariatric surgery. * Anemia (hematocrit \< 33 % or donated blood in the past 12 weeks.) * Recent (5 years or less) history of cancer * Systemic steroids or immunosuppressant use for 8 or more consecutive days in the past 6 months, or any use of anabolic steroids or growth hormones in the same period. * Body mass index \< 35 or \> 65 kg.m-2. * Acute infectious disease or chronic infection. * Pregnancy or breast-feeding. * Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation. * History of prior non-compliance that would, in the opinion of the investigator, make it difficult for the subject to comply with the study procedures or follow the investigator's instructions. * Concurrent participation in another research study. * Use of an investigational agent in the 30 days prior to signing informed consent.
Contact & Investigator
Emily J Lantz, PhD
PRINCIPAL INVESTIGATOR
The University of Texas Medical Branch
Frequently Asked Questions
Who can join the NCT07178704 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Bariatric Surgery Patients. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07178704 currently recruiting?
Yes, NCT07178704 is actively recruiting participants. Contact the research team at ejlantz@utmb.edu for enrollment information.
Where is the NCT07178704 trial being conducted?
This trial is being conducted at Galveston, United States.
Who is sponsoring the NCT07178704 clinical trial?
NCT07178704 is sponsored by The University of Texas Medical Branch, Galveston. The principal investigator is Emily J Lantz, PhD at The University of Texas Medical Branch. The trial plans to enroll 100 participants.