NCT05468255 The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults
| NCT ID | NCT05468255 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Old Dominion University |
| Condition | Glucose Intolerance |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2022-07-25 |
| Primary Completion | 2025-01-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2022-07-25 with a primary completion date of 2025-01-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.
Eligibility Criteria
Inclusion Criteria: 1. 55 years and older, 18-40 years old 2. Healthy, physically active, performing at least 90 min/week of physical activity 3. Free of physical limitations that may interfere with alterations in daily physical activity levels Exclusion Criteria: 1. Physician diagnosed HIV, hepatitis, or tuberculosis. 2. Body weight change of greater than 5% within the previous 2 months 3. Smoking within the previous 2 months. 4. Taking medications that alter blood glucose levels
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05468255 clinical trial?
This trial is open to participants of all sexes, studying Glucose Intolerance. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05468255 currently recruiting?
Yes, NCT05468255 is actively recruiting participants. Contact the research team at lreynold@odu.edu for enrollment information.
Where is the NCT05468255 trial being conducted?
This trial is being conducted at Norfolk, United States.
Who is sponsoring the NCT05468255 clinical trial?
NCT05468255 is sponsored by Old Dominion University. The trial plans to enroll 40 participants.