NCT06733168 The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
| NCT ID | NCT06733168 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Vietnam Military Medical University |
| Condition | Acute Respiratory Syndrome Distress |
| Study Type | INTERVENTIONAL |
| Enrollment | 76 participants |
| Start Date | 2024-08-15 |
| Primary Completion | 2026-12-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 76 participants in total. It began in 2024-08-15 with a primary completion date of 2026-12-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of ventilator-induced lung injury (VILI). Positive end-expiratory pressure (PEEP), a fundamental component of MV, is widely utilized in clinical practice; however, optimal PEEP selection for patients with moderate to severe ARDS remains a complex and unresolved challenge. Electrical impedance tomography (EIT), a bedside imaging modality that evaluates regional ventilation distribution, offers a means of individualizing PEEP settings in mechanically ventilated patients. By balancing the competing risks of alveolar overdistension and collapse, EIT facilitates precision in PEEP titration. This study compares the impact of EIT-guided PEEP selection versus the conventional low FiO2-PEEP table on blood oxygenation and pulmonary mechanics.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years. * Intubated moderate and severe ARDS according to the New Global Definition (PaO2/FiO2 ≤200 mmHg). * Used continuous sedation with or without paralysis. Exclusion Criteria: * Presence of pneumothorax that is either undrained or newly occurred. * Unstable hemodynamics with a mean arterial pressure \< 60 mmHg and unresponsive to resuscitation measures, and/or heart rate \< 60 bpm. * Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application). * Pregnancy. * Severe neuromuscular disease.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06733168 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Acute Respiratory Syndrome Distress. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06733168 currently recruiting?
Yes, NCT06733168 is actively recruiting participants. Contact the research team at dinhvantrung.ptgh@gmail.com for enrollment information.
Where is the NCT06733168 trial being conducted?
This trial is being conducted at Hanoi, Vietnam.
Who is sponsoring the NCT06733168 clinical trial?
NCT06733168 is sponsored by Vietnam Military Medical University. The trial plans to enroll 76 participants.