NCT03959904 The Impact of Abdominal Wall Closure Technique on Incidence of Incisional Hernia in Kidney Transplantation
| NCT ID | NCT03959904 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Manchester University NHS Foundation Trust |
| Condition | Surgery--Complications |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2020-03-10 |
| Primary Completion | 2026-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2020-03-10 with a primary completion date of 2026-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
STUDY SUMMARY Incisional hernias, or swellings of the abdominal scar after surgery, remain problematic especially after transplant surgery. This is because they can cause complications, including trapping of bowel or the transplant. This can cause life threatening emergencies but is at the very least unsightly and uncomfortable for the patient. Transplant patients are especially likely to develop hernias because of the diseases causing the renal failure and the drugs that they take to dampen the immune system. There is evidence from other surgery that the stitching methods that are used to close the wounds might decrease the risk of surgical hernias. This is achieved by placing smaller and more numerous sutures (stitches) in the wound to increase the strength of the repair. However, this has never been tested formally in transplant where it may provide significant benefit. We intend to do some initial investigation of whether using the smaller stitches may provide benefit over more traditional methods that are currently being used. We will look at early complications after surgery but also the rate of hernia formation later. We hope to improve outcomes and reduce complications for our transplant patients by doing this. In addition we will collect blood and tissue samples from both live kidney donors and the recipients to microscopically analyse their collagen to identify potential factors which may indicate risk of hernia formation.
Eligibility Criteria
Inclusion Criteria: * End-stage renal failure patients * Aged 18-70yrs * First transplants or second transplants * Ability to adequately understand English and consent for study * BMI\<35 kg/m2) * Living donor nephrectomy patients Exclusion Criteria * Outside age range, * Previous transplants which have left a scar in the ilia fossa
Contact & Investigator
Frequently Asked Questions
Who can join the NCT03959904 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 70 Years, studying Surgery--Complications. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03959904 currently recruiting?
Yes, NCT03959904 is actively recruiting participants. Contact the research team at alex.shaw@mft.nhs.uk for enrollment information.
Where is the NCT03959904 trial being conducted?
This trial is being conducted at Manchester, United Kingdom.
Who is sponsoring the NCT03959904 clinical trial?
NCT03959904 is sponsored by Manchester University NHS Foundation Trust. The trial plans to enroll 50 participants.