NCT06737224 The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults
| NCT ID | NCT06737224 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of British Columbia |
| Condition | Fasting |
| Study Type | INTERVENTIONAL |
| Enrollment | 15 participants |
| Start Date | 2025-01-10 |
| Primary Completion | 2025-08-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 15 participants in total. It began in 2025-01-10 with a primary completion date of 2025-08-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans. Moreover, how exercising during a prolonged fast impacts immunometabolic outcomes is unclear. This study will determine how a 2 day fast - performed with or without daily exercise - impacts immune cell bioenergetics, immune cell function, and whole-body glycemic control in healthy active individuals.
Eligibility Criteria
Inclusion Criteria: * Aged between 19 and 35 years. * Physically active (engaging in ≥150 minutes of weekly moderate to vigorous physical activity). Exclusion Criteria: * History of cardiometabolic diseases or inflammatory diseases (e.g., chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, cardiovascular disease). * Individuals currently following a ketogenic diet, low-calorie diet, periodic fasting regimen, or consuming ketogenic supplements (e.g., exogenous ketone drinks). * Cigarette/vaping smoking. * Physical limitation that will impair the ability of the participant to perform exercise. * Individuals having a body mass index (BMI) over 30 kg/m2. * Cancer diagnosis in the past 5 years. * Taking anti-inflammatory drugs (e.g., ibuprofen, aspirin, naproxen). * Being unable to read or communicate in English.
Contact & Investigator
Jonathan Little Principal Investigator, Professor Little, Ph.D
✉ jonathan.little@ubc.ca📞 250-807-9876
Frequently Asked Questions
Who can join the NCT06737224 clinical trial?
This trial is open to participants of all sexes, aged 19 Years or older, up to 35 Years, studying Fasting. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06737224 currently recruiting?
Yes, NCT06737224 is actively recruiting participants. Contact the research team at jonathan.little@ubc.ca for enrollment information.
Where is the NCT06737224 trial being conducted?
This trial is being conducted at Kelowna, Canada.
Who is sponsoring the NCT06737224 clinical trial?
NCT06737224 is sponsored by University of British Columbia. The trial plans to enroll 15 participants.