NCT06431425 The Electronic Cardiovascular Genetics (eCG) Clinic for Presymptomatic Genetic Counselling
| NCT ID | NCT06431425 |
| Status | Recruiting |
| Phase | — |
| Sponsor | UMC Utrecht |
| Condition | Inherited Cardiac Disease |
| Study Type | INTERVENTIONAL |
| Enrollment | 170 participants |
| Start Date | 2023-11-15 |
| Primary Completion | 2026-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 170 participants in total. It began in 2023-11-15 with a primary completion date of 2026-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Inherited cardiovascular conditions generally inherit following an autosomal dominant pattern. When a mutation is detected in the proband, relatives can have predictive DNA testing, and - when they are carrier - be monitored and timely treated if needed. Currently, less than half of relatives attends genetic counselling. With the eCG Family Clinic, an easily accessible virtual clinic which better suits the needs and preferences of relatives will be offered. At the eCG Family Clinic, relatives will receive tailored information to support informed decision-making, a DNA-test at home if desired, and can be referred for local cardiac monitoring if relatives appear to be a carrier. Implementation of the eCG Family Clinic in clinical practice is compared to current practice in this clinical trial.
Eligibility Criteria
Inclusion Criteria: Probands: * \> 18 y/o * Diagnosed with inherited hypertrophic cardiomyopathy (HCM) or dialted cardiomyopathy (DCM)) * Class 4 or 5 variant identified. * Access to a working laptop or computer device. At risk relatives: * \> 18 y/o * First degree family member, or second degree in case of a deceased first degree relative * Access to a working laptop or computer device. Healthcare professionals: \- Genetic counsellors of the genetics department directly involved in the care given to the family. Exclusion Criteria: \- Insufficient control of the Dutch language or digital skills.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06431425 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 90 Years, studying Inherited Cardiac Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06431425 currently recruiting?
Yes, NCT06431425 is actively recruiting participants. Contact the research team at m.n.vanlingen@umcutrecht.nl for enrollment information.
Where is the NCT06431425 trial being conducted?
This trial is being conducted at Utrecht, Netherlands.
Who is sponsoring the NCT06431425 clinical trial?
NCT06431425 is sponsored by UMC Utrecht. The trial plans to enroll 170 participants.