NCT06571721 The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles
| NCT ID | NCT06571721 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Integrative Skin Science and Research |
| Condition | Collagen Degeneration |
| Study Type | INTERVENTIONAL |
| Enrollment | 90 participants |
| Start Date | 2024-07-22 |
| Primary Completion | 2025-01-22 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 90 participants in total. It began in 2024-07-22 with a primary completion date of 2025-01-22.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.
Eligibility Criteria
Inclusion Criteria: * Post-menopausal women of Fitzpatrick skin types 1, 2, and 3 * Individuals with facial fine lines and wrinkles Exclusion Criteria: * Individuals who are pregnant or breastfeeding * Prisoners * Adults unable to consent * Those with a nut allergy or tocopherol allergy * Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking * Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes) * Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment * Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention * Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment: * Retinoids such as tretinoin, adapalene, retinol, except as provided by the study. * Antioxidant ingredients such as vitamin C or vitamin E. * Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study. * Topicals that contain a nut oil or nut extract as part of their ingredient list.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06571721 clinical trial?
This trial is open to female participants only, aged 18 Years or older, studying Collagen Degeneration. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06571721 currently recruiting?
Yes, NCT06571721 is actively recruiting participants. Contact the research team at nasima@integrativeskinresearch.com for enrollment information.
Where is the NCT06571721 trial being conducted?
This trial is being conducted at Sacramento, United States.
Who is sponsoring the NCT06571721 clinical trial?
NCT06571721 is sponsored by Integrative Skin Science and Research. The trial plans to enroll 90 participants.