The Effects of Hydroxychloroquine in Patients with Inflammatory Cardiomyopathy
Trial Parameters
Brief Summary
Evaluating the long-term therapeutic effects and safety of hydroxychloroquine(compared to glucocorticoid therapy alone) in patients with inflammatory cardiomyopathy--a multicenter randomized controlled study
Eligibility Criteria
Inclusion criteria: 1. Male or female patient aged from 18 to 80 years; 2. Left ventricular dysfunction \[left ventricular ejection fraction (LVEF) \<50%\] diagnosed by echocardiography (Simpson's biplane) within 30 days before randomization; 3. Chronic heart failure (lasting \>6 months) unresponsive to conventional supportive therapy; 4. High-sensitivity cardiac Troponin I (hs-cTnI) \>26.2 pg/mL and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) \>169pg/mL; 5. Suffered from confirmed fulminant myocarditis in the past; 6. Diagnosed with chronic inflammatory cardiomyopathy confirmed by myocardial biopsy1; 7. Absence of cardiotropic viruses at polymerase chain reaction analysis; 8. Volunteer for the study and written informed consent; Exclusion criteria: 1. Age \<18 or \>80 years; 2. Acute myocardial infarction occurred within the past month; 3. Subjects who have undergone cardiac surgery or cerebrovascular accidents within 6 months; 4. Preparing for heart transplantation; 5. With