The Effects of an Oral Nutritional Intervention on the Small Intestine Microbiome
Trial Parameters
Brief Summary
This is a single-center, single-arm study, aiming at enrolling 25 healthy adult participants to evaluate chronic effects of oil. Specifically, we aim to assess the impact on gut microbiome after a one-month intervention with oil.
Eligibility Criteria
Inclusion Criteria: 1. Males or females aged 18 to 60 years, inclusive, at enrollment. 2. BMI of ≥18.5 but \<30 kg/m2. 3. Healthy, as determined based on self-reported medical history. 4. No planned change in diet or medical interventions during the study. 5. Willing to collect fecal samples and retrieve sampling capsules from feces. 6. Able to understand and to sign a written informed consent prior to study enrollment. 7. Willing and able to comply with the requirements for participation in this study. Exclusion Criteria: 1. Prior or suspected gastrointestinal disease (as reported by the participant) which, in the investigator/study doctor's opinion, would lead to fistula formation, intestinal stricturing, or obstruction leading to a risk of capsule non-excretion (i.e. achalasia, active ulcer disease, eosinophilic esophagitis, Crohn's disease, ulcerates colitis, celiac disease, irritable bowel syndrome, stenosis of the GI tract). 2. Any prior gastrointestinal surgery (as reported by t