NCT06532851 The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
| NCT ID | NCT06532851 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Jordan University of Science and Technology |
| Condition | Meniscus Tear |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2023-06-01 |
| Primary Completion | 2030-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2023-06-01 with a primary completion date of 2030-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears. 45 participants, aged 35-55, will be randomly assigned to one of three groups: PRE, aerobic exercise, or control (standard of care physical and medical therapy). The study will utilize MRI T2 mapping to assess changes in cartilage composition and patient-reported and performance-based measures to evaluate clinical outcomes. This pilot study will also determine the feasibility and issues related to recruitment and retention for a larger trial.
Eligibility Criteria
Inclusion Criteria: 1. Are between 35 and 55 years of age. 2. Have a symptomatic degenerative medial meniscus tear as evidenced by: * Presence of medial knee pain. * Medial joint line tenderness. * Pain and limited motion when attempting to perform a full squat and * Increased intra-meniscal signal on at least 2 consecutive MRI slices and 3. Have clearance from their personal physician to participate in an exercise program. Exclusion Criteria: 1. Radiographic evidence of OA (K-L grade 2 or above). 2. A repairable meniscus injury (longitudinal tear in the outer 1/3 of the meniscus). 3. A meniscus injury that requires meniscectomy (locked knee). 4. Prior or current ligament injury or surgery of the involved knee. 5. Prior or current injury or surgery to contra-lateral knee. 6. Pathological ligamentous laxity upon examination of the knee 7. An inflammatory arthritic condition or 8. Any injury or condition involving the lower extremities that affects their ability to walk. Because participation in this study requires undergoing MRI, subjects will be excluded if they: 1. If female, pregnant at the time of enrollment. 2. Had prior surgery for an aneurysm; any medical illness that may interfere with the patient's general fitness or exercise capability. 3. Had any contraindication with MRI. 4. Had surgery within the past two months. 5. Have a cardiac pacemaker.
Frequently Asked Questions
Who can join the NCT06532851 clinical trial?
This trial is open to participants of all sexes, aged 35 Years or older, up to 55 Years, studying Meniscus Tear. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06532851 currently recruiting?
Yes, NCT06532851 is actively recruiting participants. Visit ClinicalTrials.gov or contact Jordan University of Science and Technology to inquire about joining.
Where is the NCT06532851 trial being conducted?
This trial is being conducted at Ar Ramtha, Jordan, Irbid, Jordan.
Who is sponsoring the NCT06532851 clinical trial?
NCT06532851 is sponsored by Jordan University of Science and Technology. The trial plans to enroll 50 participants.