NCT07496905 The Effect of the Valsalva Maneuver in Endometrial Biopsy: A Randomized Controlled Trial
| NCT ID | NCT07496905 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization |
| Condition | Pain in Endometrial Biopsy |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2025-01-01 |
| Primary Completion | 2026-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2025-01-01 with a primary completion date of 2026-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Endometrial sampling with a pipelle is a common procedure used to collect a small sample from the lining of the uterus. During the procedure, the cervix is sometimes held with a surgical instrument called a tenaculum, which may cause pain and anxiety for some women. The Valsalva maneuver is a simple technique in which a person takes a deep breath and pushes as if trying to exhale forcefully. This increases pressure inside the abdomen and may help keep the uterus and cervix more stable during the procedure. This study aims to compare pipelle sampling performed with the Valsalva maneuver to the standard method using a tenaculum. The study will evaluate whether the Valsalva maneuver can reduce pain and anxiety while maintaining procedure success and improving patient satisfaction.
Eligibility Criteria
Inclusion Criteria: -Endometrial sampling indication in reproductive age group of patients over 18 years of age, who can communicate in Turkish. Exclusion Criteria: * Patients under 18 years of age - postmenopausal * Pregnancy * Patients with known stenotic cervical os * Patients with a history of acute cervicitis; * Patients with intense anxiety; * Need for simultaneous endocervical curettage; * Need for general or local anesthesia * Having used analgesic medication before the procedure; * History of a known malignancy, uterine anomaly, or leiomyoma affecting the cervical canal or uterine cavity, or uterine prolapse; * Patients with known chronic plevic pain
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07496905 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 55 Years, studying Pain in Endometrial Biopsy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07496905 currently recruiting?
Yes, NCT07496905 is actively recruiting participants. Contact the research team at neslihanoztopuz@gmail.com for enrollment information.
Where is the NCT07496905 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07496905 clinical trial?
NCT07496905 is sponsored by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization. The trial plans to enroll 120 participants.