NCT06985420 The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise
| NCT ID | NCT06985420 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Central Florida |
| Condition | Healthy Women |
| Study Type | OBSERVATIONAL |
| Enrollment | 40 participants |
| Start Date | 2024-08-16 |
| Primary Completion | 2025-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 40 participants in total. It began in 2024-08-16 with a primary completion date of 2025-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to learn how the menstrual cycle affects immune cell activation, recruitment, and recovery responses after resistance exercise in healthy, resistance-trained women aged 18-40. The main questions it aims to answer are: Does the menstrual cycle influence neutrophil recruitment and adhesion after resistance exercise? Does the menstrual cycle affect markers of muscle damage and functional recovery? Researchers will compare three menstrual phases (early follicular, late follicular, and mid-luteal) to see if immune responses and recovery outcomes differ across these phases. Participants will: Complete resistance exercise protocols across three different menstrual cycle phases. Provide blood samples to assess immune cell activation and muscle damage markers. Track sleep, mood, and recovery with questionnaires and wear an accelerometer.
Eligibility Criteria
Inclusion Criteria: * Women between the ages of 18 and 40. * Must weigh at least 110 pounds. * Healthy as determined by medical history, physical activity readiness, and menstrual cycle questionnaires. * Actively resistance training for at least 6 months (minimum of 3 resistance training sessions per week, with at least one lower body session). * Pre-menopausal and have a regular menstrual cycle (eumenorrheic), with a clear start of menses (early follicular phase). * Not currently pregnant or planning to become pregnant during the study. * Have not used hormonal birth control or intrauterine devices in the past 3 months (or three full menstrual cycles). * Able to recall approximate start dates of their last 6 menstrual cycles. * Willing to follow study instructions, including avoiding exercise, alcohol, and caffeine before testing visits. * Free from previous or current lower body injuries that could limit performance. * Not regularly taking any medications that could interfere with the study. * Determined to have a high likelihood of successful blood draws by a certified phlebotomist. Exclusion Criteria: * Do not give consent to participate. * Have been determined unfit to participate based on medical or activity history (using health questionnaires). * Currently take prescription or over-the-counter medication that could affect the study results. * Have a chronic illness requiring medical care. * Not currently resistance-trained (don't meet the exercise requirement). * Pregnant or planning to become pregnant during the study. * Do not have regular periods or have been diagnosed as amenorrhoeic (absence of menstruation). * Currently taking any performance-enhancing drugs. * Currently using hormonal birth control or intrauterine devices (IUDs), or have used them in the past three months (or three full menstrual cycles). * Determined unlikely to have a successful blood draw by a trained phlebotomist. * Weigh less than 110 pounds.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06985420 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 40 Years, studying Healthy Women. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06985420 currently recruiting?
Yes, NCT06985420 is actively recruiting participants. Contact the research team at jessica.moon@ucf.edu for enrollment information.
Where is the NCT06985420 trial being conducted?
This trial is being conducted at Orlando, United States.
Who is sponsoring the NCT06985420 clinical trial?
NCT06985420 is sponsored by University of Central Florida. The trial plans to enroll 40 participants.