NCT06203847 The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA
| NCT ID | NCT06203847 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Taiwan University Hospital |
| Condition | Cardiac Arrest |
| Study Type | INTERVENTIONAL |
| Enrollment | 1,344 participants |
| Start Date | 2024-07-16 |
| Primary Completion | 2026-07-31 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have been resuscitated by advanced paramedics, the intervention group that receives combined drug treatment (epinephrine, vasopressin, methylprednisolone) has a better rate of sustained recovery of spontaneous circulation (ROSC) (primary outcome) and long-term survival status (secondary outcomes) compared to the control group that receives single drug treatment (epinephrine).
Eligibility Criteria
Inclusion Criteria: * Adult patients (aged \>= 18 ) * Out-of-hospital cardiac arrest in the studied regions * Treated by paramedics authorized and capable of giving prehospital medication Exclusion Criteria: * OHCA with traumatic etiology * Obvious signs of death like decapitation, rigor mortis, livor mortis, decomposition, etc. * DNR (Do Not Resuscitation) or termination of resuscitation requested by the family * Patients with known or suspected pregnancy * No vascular access was established before hospital arrival * ROSC before the administrated medication * No patient contact (cancelled ambulance call or the patient was transported to the hospital before the arrival of trial-trained paramedics) * Received epinephrine prior to the arrival of trial-trained paramedics