NCT06753396 The Effect of Injectable Platelet-Rich Fibrin in Peri-implant Soft Tissue
| NCT ID | NCT06753396 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Kutahya Health Sciences University |
| Condition | Peri-Implant Tissues |
| Study Type | INTERVENTIONAL |
| Enrollment | 80 participants |
| Start Date | 2022-12-15 |
| Primary Completion | 2025-12-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 80 participants in total. It began in 2022-12-15 with a primary completion date of 2025-12-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
An inadequate amount of peri-implant soft tissue results in more plaque accumulation around the implants, peri-implant mucositis, marginal bone loss, mucosal recession, and/or attachment loss. In the literature, there are studies evaluating the application of injectable platelet-rich fibrin to the gingiva and oral mucosa around teeth, but injectable platelet-rich fibrin application around implants has not been encountered. This study aimed to evaluate the effect of subgingival and submucosal application of injectable platelet-rich fibrin on peri-implant soft tissue phenotype in patients with inadequate peri-implant soft tissue phenotype.The study will include 80 systemically healthy and non-smoking patients/implants older than 18 years of age with insufficient peri-implant keratinized mucosa width and mucosal thickness who applied to Kütahya University of Health Sciences, Faculty of Dentistry, Department of Periodontology. There are two study groups according to peri-implant mucosa phenotype: Thin phenotype and thick phenotype. All patients will undergo the same procedure of injectable platelet-rich fibrin application
Eligibility Criteria
Inclusion Criteria: 1. be over 18 years old 2. The patient does not have any systemic disease 3. Patients who do not smoke or who smoke less than 10 cigarettes 4. Peri-implant keratinized mucosa width less than 2 mm 5. Peri-implant mucosal thickness less than 2 mm Exclusion Criteria: 1. Being out of the defined age group 2. Any systematic contraindication for periodontal surgery 3. Patients who smoke more than 10 cigarettes per day 4. Patients with adequate peri-implant keratinized mucosa width and mucosal thickness 5. Pregnancy 6. Patients taking medication that suppresses the immune system or impairs healing 7. Patients taking medication that impairs the bleeding condition
Contact & Investigator
Berceste Güler Ayyıldız, Assoc. Prof. Dr
STUDY DIRECTOR
Kütahya Health Sciences University
Frequently Asked Questions
Who can join the NCT06753396 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Peri-Implant Tissues. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06753396 currently recruiting?
Yes, NCT06753396 is actively recruiting participants. Contact the research team at berceste.guler@ksbu.edu.tr for enrollment information.
Where is the NCT06753396 trial being conducted?
This trial is being conducted at Kütahya, Turkey (Türkiye).
Who is sponsoring the NCT06753396 clinical trial?
NCT06753396 is sponsored by Kutahya Health Sciences University. The principal investigator is Berceste Güler Ayyıldız, Assoc. Prof. Dr at Kütahya Health Sciences University. The trial plans to enroll 80 participants.