NCT06587880 The Effect of Different Types of Mouthwash on Extraction Sockets' Healing
| NCT ID | NCT06587880 |
| Status | Recruiting |
| Phase | Phase 4 |
| Sponsor | University of Jordan |
| Condition | Extraction Socket Healing |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2025-08-10 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 4 studies follow an already-approved treatment in real-world conditions to monitor long-term safety and effectiveness.
This trial targets 100 participants in total. It began in 2025-08-10 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to assess the effect of four different types of mouthwash on socket healing after surgical extractions in male or female patients aged 18 years and older who have a unilateral impacted mandibular third molar indicated for extraction. The main questions it aims to answer are: The effect of Bone Bioactive Liquid (BBL) mouthwash, Hyaluronic Acid (HA) mouthwash, the Chlorhexidine digluconate (CHX) mouthwash and Warm Saline Mouth Rinse (WSMR) on socket healing after surgical extractions. The effect of BBL mouthwash, HA mouthwash, the CHX mouthwash and WSMR on patient related factors and their quality of life. Recruited Participants will be randomized into four intervention groups: 1. First group will receive BBL mouthwash. 2. The second group will receive CHX mouthwash. 3. The third group will be prescribed HA mouthwash. 4. The fourth group will receive Warm Saline Mouth Rinse.
Eligibility Criteria
Inclusion Criteria: * Male or female patients aged 18 years and older who have a unilateral impacted mandibular third molar that is indicated for extraction with bone removal and the presence of an adjacent second molar. Exclusion Criteria: * Soft tissue impaction that will not need any bone removal. * Presence of any acute oral infection including active Pericoronitis. * Patients who have undergone radiotherapy in the head and neck region, chemotherapy or systemic long-term corticosteroid treatment. * Patients receiving medications known to induce gingival hyperplasia; anticonvulsant (phenytoin), immunosuppressant (cyclosporine A), and various calcium channel blockers (nifedipine, verapamil, diltiazem). * Patients who have taken systemic antibiotics less than 3 months prior to baseline. * Presence of uncontrolled diabetes, severe nutritional deficiencies and endocrine disturbances. * Presence of immune deficiency or any immune disease. * Intravenous bisphosphonates or Oral bisphosphonate intake for more than 3 years. * Smokers and alcoholics. * Pregnant or lactating females. * Hypersensitivity to one of the ingredients listed in any of the mouthwashes, especially chlorhexidine as reactions to this has been reported in the literature.
Contact & Investigator
Ahmad Hamdan, Ph.D. in Periodontics
PRINCIPAL INVESTIGATOR
Faculty of Dentistry - University of Jordan
Frequently Asked Questions
Who can join the NCT06587880 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Extraction Socket Healing. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06587880 trial and what does that mean for participants?
Phase 4 studies are conducted after a treatment has been approved. They monitor long-term safety and real-world effectiveness in a broader patient population.
Is NCT06587880 currently recruiting?
Yes, NCT06587880 is actively recruiting participants. Contact the research team at Ahmad.hamdan@ju.edu.jo for enrollment information.
Where is the NCT06587880 trial being conducted?
This trial is being conducted at Amman, Jordan.
Who is sponsoring the NCT06587880 clinical trial?
NCT06587880 is sponsored by University of Jordan. The principal investigator is Ahmad Hamdan, Ph.D. in Periodontics at Faculty of Dentistry - University of Jordan. The trial plans to enroll 100 participants.