NCT05332457 The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation
| NCT ID | NCT05332457 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Taiwan University Hospital |
| Condition | Atrial Fibrillation |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2025-07-01 |
| Primary Completion | 2025-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2025-07-01 with a primary completion date of 2025-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a prospective study to evaluate changes in exercise capacity and chronotropic response to exercise before and after beta-blocker dosage reduction in patients with atrial fibrillation (AF).
Eligibility Criteria
Inclusion Criteria: 1. \> 20 years of age. 2. Clinically stable patients with persistent atrial fibrillation using beta-blocker as rate-control agent without dosage adjustment for at least 3 months. 3. Resting heart rate \< 80 bpm. 4. Left ventricular ejection fraction \> 50%. Exclusion Criteria: 1. Beta-blocker usage due to indications other than rate control for atrial fibrillation. 2. Inability to perform a cardiopulmonary exercise testing. 3. Presence of contraindications for cardiopulmonary exercise testing according to the American College of Sports Medicine's Guidelines for Exercise Testing and Prescription. 4. Patients with implantable cardioverter defibrillator or pacemaker. 5. Pregnancy. 6. Inability to provide informed consent.
Contact & Investigator
Hung-Jui Chuang, MD
PRINCIPAL INVESTIGATOR
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital
Frequently Asked Questions
Who can join the NCT05332457 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, studying Atrial Fibrillation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05332457 currently recruiting?
Yes, NCT05332457 is actively recruiting participants. Contact the research team at 103311@ntuh.gov.tw for enrollment information.
Where is the NCT05332457 trial being conducted?
This trial is being conducted at Taipei, Taiwan.
Who is sponsoring the NCT05332457 clinical trial?
NCT05332457 is sponsored by National Taiwan University Hospital. The principal investigator is Hung-Jui Chuang, MD at Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital. The trial plans to enroll 40 participants.
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